Itay Tirosh Lab

The Zuckerman Faculty Scholars program, funds leading researchers and supports the purchase and construction of laboratories and specialized equipment. The program thus provides vital resources to Israeli universities, allowing them to compete with top North American institutions for the most promising candidates.

The program facilitates the return of top Israeli scholars to Israeli institutions, cultivates world class scientific talent, and in turn, attracts outstanding postdoctoral researchers from top Western universities, creating a cycle of excellence.

Since the program opened in 2016, 16 Zuckerman labs have been established in Israel.

Interested in applying for the faculty scholars program?

Eligibility
ITAY
Principal Investigator
Dr. Itay Tirosh

Zuckerman Faculty Scholar
at the Weizmann Institute of Science

ITAY

Itay Tirosh Lab

TUMOR SYSTEMS BIOLOGY
Lab Established 2018

Lab research areas

The lab combines computational and experimental methods to study human tumors as a complex ecosystem in which diverse cancer and non-cancer cells interact and collectively determine tumor biology and response to therapies. Lab researchers leverage single cell technologies, computational approaches and clinical collaborations to analyze the diversity of cells within human tumors. They focus on identifying important tumor subpopulations such as cancer stem cells, drug resistant cells, invasive cells, and immune cells that respond to immunotherapies. They then study their function, regulation, and vulnerabilities, with the ultimate goal of developing better cancer treatments.

Scholar Profile

Dr. Tirosh completed his PhD in the Department of Molecular Genetics at the Weizmann Institute of Science, where he studied gene expression in yeast.

During his postdoctoral fellowship at the Broad Institute of MIT and Harvard, he pioneered the application of single-cell RNA­Seq to solid human tumors. Collaborating with clinicians at Boston hospitals, he established a general approach to studying intra-tumor heterogeneity and revealing clinically important subpopulations. His studies showed the ways single-cell genomics offers insights with implications for both targeted and immune therapies.

At the Department of Molecular Cell Biology at Weizmann, Dr. Tirosh’s joint computational and experimental research group studies solid tumors as a complex ecosystem. His work has potential for improvements in cancer research and ultimately cancer therapy.

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