ZUCKERMAN STEM LABS

SPIEGEL LAB
HOW EXPERIENCE REGULATES BRAIN FUNCTION
Dr.
Dr. Ivo Spiegel
Principal Investigator

Zuckerman Faculty Scholar

at Weizmann Institute of Science

Lab Established in 2017
Zuckerman Scholars

Lab research areas

The laboratory researches the ability to adapt to and learn from experiences, which underlies many of our cognitive capabilities. Lab researchers seek to identify the molecular mechanisms through which neural circuits adapt to experience, and to understand how the cellular functions that are regulated by these molecular mechanisms generate an animal’s adaptive behavior. They focus on signaling and transcriptional networks. They apply genomic, molecular, biochemical, electrophysiological and behavioral approaches to understanding how experience-induced signaling and transcriptional networks in subtypes of cortical neurons regulate the connectivity and function of the cortex. Researchers believe this will allow them to untangle how nature and nurture cooperate to regulate adaptive behavior and to understand how mutations in the genome might give rise to psychiatric disorders and to individual variation in cognitive capabilities.

Scholar Profile

Dr. Spiegel has returned to the Weizmann Institute, where he received his MSc and PhD in the Department of Molecular Cell Biology. He is currently in the Department of Neurobiology. Dr. Spiegel was born in Basel, Switzerland, and moved to Israel after high school. He went to Tel Aviv University, where he became fascinated by molecular and cellular biology, and by neuroscience. His career was at first devoted to neuronal cell biology, but during his postdoctoral work at Harvard Medical School, he decided to shift to the challenging question of how gene regulation programs control circuit formation in the brain.

At Weizmann, Dr. Spiegel has established his own independent research group, called “How Experience Regulates Brain Function.” The lab uses a highly multidisciplinary approach.