Coming to the Weizmann Institute of Science from the Broad Institute of MIT and Harvard, Dr. Tirosh is studying the multicellular ecosystems of solid tumors. He completed his PhD in the Department of Molecular Genetics at the Weizmann Institute of Science, where he studied gene expression in yeast.
During his postdoctoral fellowship at the Broad Institute of MIT and Harvard, he pioneered the application of single-cell RNASeq to solid human tumors. Collaborating with clinicians at Boston hospitals, he established a general approach to studying intra-tumor heterogeneity and revealing clinically important subpopulations. His studies showed the ways single-cell genomics offers insights with implications for both targeted and immune therapies.
At the Department of Molecular Cell Biology at Weizmann, Dr. Tirosh will be establishing a joint computational and experimental research group that will study solid tumors as a complex ecosystem. His work has potential for improvements in cancer research and ultimately cancer therapy.